Skip to content


( EDDP )

Cut-Off Levels (ng/mL)
Window of Detection
200, 300 ng/mL (Urine) 2 hr. - 3 Days (Urine)
50, 300 ng/mL (Saliva) 1 - 2 (Saliva)

What is Methadone? 

Methadone is a synthetic opioid which was created after WWII due to a shortage in Morphine. Today it is commonly prescribed to patients suffering from opioid withdrawal and for pain management. After consumption of Methadone the body will metabolize a compound known as EDDP. It is important to know this for when screening a user of Methadone, whether it be to ensure proper use or detect abuse, it remains the most reliable option.

Common Nicknames

Chocolate Chip Cookies
Street Methadone

How is it Used?

Methadone can be administered orally in a tablet or liquid form and by injection. 

What Does it Look Like?

Methadone is available as a tablet, oral solution, or injectable liquid. Tablets are available in 5 mg and 10 mg formulations. As of January 1, 2008, manufacturers of methadone hydrochloride tablets 40 mg (dispersible) have voluntarily agreed to restrict distribution of this formulation to only those facilities authorized for detoxification and maintenance treatment of opioid addiction, and hospitals. Manufacturers will instruct their wholesale distributors to discontinue supplying this formulation to any facility not meeting the above criteria. 

Common Symptoms

Muscle Tremors
Abdominal Cramps

What Are the Effects?

Abuse of methadone can lead to psychological dependence. When an individual uses methadone, he/she may experience physical symptoms like sweating, itchy skin, or sleepiness. Individuals who abuse methadone risk becoming tolerant of and physically dependent on the drug. When use is stopped a user may suffer from withdrawal symptoms similar to that of other opioids.

Legal Status

Schedule II substance under the U.S. Controlled Substance Act. Non-Medical use of Methadone is illegal.